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KMID : 1143420200130271969
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Public Health Weekly Report
2020 Volume.13 No. 27 p.1969 ~ p.1978
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Case Report of Laboratory-Acquired Vaccinia Virus Infection-South Korea, 2019
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Hyun Jung-Hee
Kim Hwa-Mi
Gwack Jin
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Abstract
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On September 27, 2019, the Division of Emerging Infectious Diseases Response, Korea Centers for Disease Control and
Prevention (KCDC) was notified of an inadvertent inoculation of a laboratory researcher with the vaccinia virus Wyeth strain. The vaccinia virus is a pathogen that belongs to the poxvirus family. It is not a pathogen for statutory infectious diseases, but secondary infection is possible when exposed directly to a patient's lesion. An investigation conducted by the KCDC and Gyeongsangnam Province suspected that the researcher, who reported a spattering on their forehead while filtering the vaccinia virus solution, had been infected. The patient had one lesion on the center of their forehead that appeared to be due to the vaccinia virus. The pustule blistered from the center and formed a scar over the course of 3 weeks. Apart from the lesion, the patient showed no symptoms; no fever, chills, or other systemic or neurologic symptoms. Through an epidemiologic investigation 13 people were classified as contacts who required monitoring. They were followed up with by the public health center and the hospital infection control team for 21 days. During that period, no one reported any symptoms. On October 28, 2019, the monitoring was lifted for these contacts. After the incident, measures were taken to prevent similar accidents through the additional training of laboratory safety coupled with effective biosafety protocols such as the education of laboratory personnel, safe laboratory practice, and incident reporting. The vaccinia virus infection does not belong to the national notifiable infectious diseases. However, it has a risk of transmission that requires epidemiologic investigation, laboratory tests and public health countermeasures.
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KEYWORD
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Vaccinia virus, Laboratory acquired infection
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